[Pseudo-scleroderma and Diabetic bullae: about one case]

Pseudo-scleroderma states associated with diabetes mellitus are rare and their association with diabetic bullae [bullosis diabeticorum] has never been reported. We report a case of diabetic pseudo scleroderma in a lower limb linked to a diabetic bullae in a 52 year old patient, hospitalized for several diabetic complications. The patient reported the occurrence of bullous lesions over the two legs. On examination, the skin of the legs and the thighs had bilaterally a cardboard-like texture, was painless, with no articular limitation, evoking scleroderma or dermatopolymyositis. The electro-myogram revealed the presence of sensory and motor neuropathy related to diabetes

[Prognostic factors for surgical cure in acromegaly]

Surgery is the treatment of choice in acromegaly. To determine the prognostic factors for surgical cure in growth hormone secreting pituitary adenomas, we studied 35 patients who underwent surgery between 1986 and 2005. We compared the clinical, biological and tumoral characteristics of the cured group [n=19] and those of the non cured group [n=16]. A young age and in invasive adenoma were factors for a poor surgical prognosis. Other factors for bad surgical prognosis are reported in the literature such as a preoperative GH level higher than 50 ng/ml, a monohormonal finding at immunohistochemistry and no GH suppression after surgery

Primary hyperaldosteronism: about 2 cases

syndrome of primary hyperaldosteronism [PHA] includes hypertension and hypokalemia in he presence of an excessive production of aldosterone with low renin levels. The identification in a hypertensive patient is particularly interesting because this pathology is a curable ause of HTA. We report two such cases

[Diabetes and microalbuminuria: about 87 cases]

Microalbumimuria is now, considered to be the reference parameter for an early screening of diabetic renal involvement. It constitutes also a predictive marker for a cardiovascular morbidity risk. Our goal in this study was to identify the different clinical and biologic factors that may correlate .with microalbumimuria. In type 1diabetic patients, microalbumimuria was, found to be correlated with the duration of diabetes [p=0,004], the retinopathy [p< 0,001], as well as with hypertension [p=0,001]. No correlation was found with BMI, HbAlc or serum lipid levels. In type 2 diabetes, we found a correlation between microalbumimuria and BMI [p=0,008], total cholesterol [p=0, 001], HbAI C [p=0,029], serum creatinine [p=0, 04], retinopathy [p> 0, 01] and hypertension [p=0,003]. An early management of these different factors may limit the risk and the evolutivity: of diabetic nephropathy